Security performance and protocol consideration in optical communication system with optical layer security enabled by optical coding techniques

With the fast development of communication systems, network security issues have more and more impact on daily life. It is essential to construct a high degree of optical layer security to resolve the security problem once and for all. Three different techniques which can provide optical layer security are introduced and compared. Optical chaos can be used for fast random number generation. Quantum cryptography is the most promising technique for key distribution. And the optical coding techniques can be deployed to encrypt the modulated signal in the optical layer. A mathematical equation has been derived from information theory to evaluate the information-theoretic security level of the wiretap channel in optical coding schemes. And the merits and limitation of two coherent optical coding schemes, temporal phase coding and spectral phase coding, have been analysed. The security scheme based on a reconfigurable optical coding device has been introduced, and the corresponding security protocol has been developed. By moving the encryption operation from the electronic layer to the optical layer, the modulated signals become opaque to the unauthorised users. Optical code distribution and authentication is the one of the major challenges for our proposed scheme. In our proposed protocol, both of the operations are covered and defined in detail. As a preliminary draft of the optical code security protocol, it could be a useful guidance for further research

A Research on the Erupted Fetal Diseases Caused by Traditional Chinese Drugs — Discussion from the Issue that Chinese Goldthread Rhizome is Prohibited in Singapore

Chinese Goldthread Rhizome is prohibited in Singapore since it is thought to induce neonatal jaundice. In literatures of traditional Chinese medicine, this drug was never treated as a contraindicant for pregnancy, and there were no records and reports on it inducing neonatal jaundice. The results of the authors's experiments showed that Chinese Goldthread Rhizome and berberine had no induction of neonatal jaundice in pregnant rats and mice and newly born rats, and had no influence either on the activity of glucose-6-phosphate dehydrogenase of mice red blood cells. Fetal toxicity of traditional Chinese drugs including Chinese Goldthread Rhizome should be further studied in order to promote the development of traditional Chinese medicine

Identification Methods of the Deformation Memory Effect in the Stress Region above Crack Initiation Threshold

AbstractDeformation memory effect (DME) is one of the rock memory effects. One important application of the DME is to determine the in situ stress state. Compared to the traditional in situ stress measurements, the methods based on the DME are commercial and permit large number of measurements. Application of DME needs enough reliable identification methods. However, the existing methods sometimes are indistinct and the amount is insufficient. combined with three traditional methods including tangential modulus method, deformation rate analysis (DRA), acoustic emission method, two new potential methods were explored in the stress region above crack initiation threshold. One is based on the fractal dimension, called FD method. Another one is to take advantage of the lateral strain in the DRA method and the FD method, instead of using the axial strain. Based on the contact bond model in PFC2D, numerical model for granite sample was developed and cyclic uniaxial compressions were performed on it. Both the existing methods and new methods were used to detect the DME. The results demonstrate that the FD method is effective and reliable, result by DRA method with lateral strain is better than that with the axial strain, the tangential modulus method is not so distinct as other methods

The Application of Two-photon Absorbing Probes in Lysosomal, Zinc Ion Sensing and Folate Receptor-targeted Bioimaging

Two-photon fluorescence microscopy (2PFM) has become a powerful technique for bioimaging in non-invasive cancer diagnosis and also investigating the mechanization and original of a variety of diseases by tracking various biological processes. Because the fluorescence emission by two photon absorbing (2PA) is directly proportional to the square of the intensity of excitation light, this intrinsic property of 2PA provides 2PFM great advantages over traditional one-photon fluorescence microscopy (1PFM), including high 3D spatial localization, less photodamage and interference from biological tissue because of using longer wavelength excitation (700-1300 nm). However, most 2PA probes are hydrophobic and their photostabilities are questionable, severely limiting their biological and medical applications. In addition, probes with significant specificity for certain organelles for tracking cellular processes or metal ions for monitoring neural transmission are somewhat rare. Moreover, it is also very significant to deliver the probes to specific disease sites for early cancer diagnosis. In order to increase the water solubility of probes, polyethylene glycol (PEG) was introduced to a fluorene-based 2PA probe LT1 for lysosomal 2PFM cell imaging. The 2PFM bioimaging application of the novel two-photon absorbing fluorene derivative LT1, selective for the lysosomes of HCT 116 cancer cells is described in Chapter II. Linear and nonlinear photophysical and photochemical properties of the probe were investigated to evaluate the potential of the probe for 2PFM lysosomal imaging. After the investigation of the cytotoxicity of this new probe, colocalization studies of the probe with commercial lysosomal probe Lysotracker Red in HCT 116 cells were conducted. A high colocalization coefficient (0.96) was achieved and demonstrated the specific localization of the probe in lysosomes. A figure of merit, F[subscript M], was introduced by which all fluorescent probes for 2PFM can be compared. LT1 was demonstrated to have a number of properties that far exceed those of commercial lysotracker probes, including much higher 2PA cross sections, good fluorescence quantum yield, and, importantly, high photostability, all resulting in a superior figure of merit. Consequently, 2PFM was used to demonstrate lysosomal tracking with LT1. In addition to lysosomes, it is also very significant to investigate the physiological roles of free metal ions in biological processes, especially Zn²⁺, because Zn²⁺ normally serves either as the catalytic elements in enzymatic activity centers or as structural elements in enzymes and transcription factors. However, biocompatible and effective Zn²⁺ probes for 2PFM bioimaging are infrequent. In Chapter III, 2PFM bioimaging with a hydrophilic 2PA Zn²⁺ sensing fluorescent probe, bis(1,2,3-triazolyl)fluorene derivative, is described. 2PFM bioimaging of the probe in living HeLa cancer cells was demonstrated. The results revealed a significant fluorescence increase upon introduction of Zn²⁺ into the cancer cells, and a reversible Zn²⁺ binding to the probe was also demonstrated, providing a robust probe for two-photon fluorescence zinc ion sensing. Early cancer diagnosis is another critical application for 2PFM, but there are still huge challenges for this new technique in clinical areas. Most 2PA probes with large two-photon absorbing cross sections and fluorescence quantum efficiency are synthetically more accessible in hydrophobic forms. In order to increase the efficiency of the probes and minimize the effect of the probe on the human body, delivery of the probe specifically to cancer sites is desired. The synthesis and characterization of narrow dispersity organically modified silica nanoparticles (SiNPs), diameter ~30 nm, entrapping a hydrophobic two-photon absorbing fluorenyl dye, are reported in Chapter IV. The surface of the SiNPs was functionalized with folic acid to specifically deliver the probe to folate receptor (FR) over-expressing HeLa cells, making these folate 2PA dye-doped SiNPs potential candidates as probes for two-photon fluorescence microscopy (2PFM) bioimaging. In vitro studies using FR over-expressing HeLa cells demonstrated specific cellular uptake of the functionalized nanoparticles. However, when the concentration of the dye in SiNPs increased for higher signal output, the fluorescence quantum efficiency of a probe normally decreases because of self-quenching. In Chapter V, a near-infrared (NIR) emitting probe is reported to overcome this limitation through both aggregate-enhanced fluorescence emission and aggregate enhanced two-photon absorption. The dye was encapsulated in SiNPs and the surface of the nanoparticles was functionalized with PEG followed by a folic acid derivative to specifically target folate receptors. NIR emission is important for deep tissue imaging. In vitro studies using HeLa cells that upregulate folate receptors indicated specific cellular uptake of the folic acid functionalized SiNP nanoprobe. Meanwhile, the probe was also investigated for live animal imaging by employing mice bearing HeLa tumors for in vivo studies. Ex vivo 2PFM tumor imaging was then conducted to achieve high quality 3D thick tissue tumor images

Identification of novel pathways and immune profiles related to sarcopenia

IntroductionSarcopenia is a progressive deterioration of skeletal muscle mass strength and function.MethodsTo uncover the underlying cellular and biological mechanisms, we studied the association between sarcopenia's three stages and the patient's ethnicity, identified a gene regulatory network based on motif enrichment in the upregulated gene set of sarcopenia, and compared the immunological landscape among sarcopenia stages.ResultsWe found that sarcopenia (S) was associated with GnRH, neurotrophin, Rap1, Ras, and p53 signaling pathways. Low muscle mass (LMM) patients showed activated pathways of VEGF signaling, B-cell receptor signaling, ErbB signaling, and T-cell receptor signaling. Low muscle mass and physical performance (LMM_LP) patients showed lower enrichment scores in B-cell receptor signaling, apoptosis, HIF-1 signaling, and the adaptive immune response pathways. Five common genes among DEGs and the elastic net regression model, TTC39DP, SLURP1, LCE1C, PTCD2P1, and OR7E109P, were expressed between S patients and healthy controls. SLURP1 and LCE1C showed the highest expression levels among sarcopenic Chinese descent than Caucasians and Afro-Caribbeans. Gene regulatory analysis of top upregulated genes in S patients yielded a top-scoring regulon containing GATA1, GATA2, and GATA3 as master regulators and nine predicted direct target genes. Two genes were associated with locomotion: POSTN and SLURP1. TTC39DP upregulation was associated with a better prognosis and stronger immune profile in S patients. The upregulation of SLURP1 and LCE1C was associated with a worse prognosis and weaker immune profile.ConclusionThis study provides new insight into sarcopenia's cellular and immunological prospects and evaluates the age and sarcopenia-related modifications of skeletal muscle

Task Decomposition and Synchronization for Semantic Biomedical Image Segmentation

Semantic segmentation is essentially important to biomedical image analysis. Many recent works mainly focus on integrating the Fully Convolutional Network (FCN) architecture with sophisticated convolution implementation and deep supervision. In this paper, we propose to decompose the single segmentation task into three subsequent sub-tasks, including (1) pixel-wise image segmentation, (2) prediction of the class labels of the objects within the image, and (3) classification of the scene the image belonging to. While these three sub-tasks are trained to optimize their individual loss functions of different perceptual levels, we propose to let them interact by the task-task context ensemble. Moreover, we propose a novel sync-regularization to penalize the deviation between the outputs of the pixel-wise segmentation and the class prediction tasks. These effective regularizations help FCN utilize context information comprehensively and attain accurate semantic segmentation, even though the number of the images for training may be limited in many biomedical applications. We have successfully applied our framework to three diverse 2D/3D medical image datasets, including Robotic Scene Segmentation Challenge 18 (ROBOT18), Brain Tumor Segmentation Challenge 18 (BRATS18), and Retinal Fundus Glaucoma Challenge (REFUGE18). We have achieved top-tier performance in all three challenges.Comment: IEEE Transactions on Medical Imagin

A new hardware-assisted PIR with O(n) shuffle cost

Ministry of Education, Singapore under its Academic Research Funding Tier

Radar Waveform Design for Extended Target Recognition under Detection Constraints

We address the problem of radar phase-coded waveform design for extended target recognition in the presence of colored Gaussian disturbance. Phase-coded waveforms are selected since they can fully exploit the transmit power with sufficient variability. An important constraint, target detection performance, is considered to meet the practical requirements. The waveform is designed to achieve maximum recognition performance under a control on the achievable signal-to-noise ratio (SNR) of every possible target hypothesis. We formulate the code design in terms of a nonconvex, NP-hard quadratic optimization problem in the cases of both continuous and discrete phases. Techniques based on semidefinite relaxation (SDR) and randomization are proposed to approximate the optimal solutions. Simulation results show that the recognition performance and the detection requirements are well balanced and accurate approximations are achieved